Promédicaments d'inhibiteurs de transcriptase inverse de vih

Prodrugs of hiv reverse transcriptase inhibitors

Abstract

L'invention concerne des composés de formule (I); R 1 et R 2 étant définis dans la description. Les composés de formule I sont utiles pour l'inhibition de transcriptase inverse de VIH, la prophylaxie et le traitement d'infection par le VIH, et la prophylaxie, le retardement de l'apparition ou la progression, et le traitement du SIDA. Ces composés peuvent être utilisés comme ingrédients dans des compositions pharmaceutiques, éventuellement en combinaison avec d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins.
Compounds of Formula I are described: wherein R 1 and R 2 are defined herein. The compounds of Formula I are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV, and the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

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    Title
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Cited By (3)

    Publication numberPublication dateAssigneeTitle
    CN-106008362-AOctober 12, 2016杰达维(上海)医药科技发展有限公司Preparation method of novel pyrimidine derivative
    US-9469634-B2October 18, 2016Merck Sharp & Dohme Corp.Non-nucleoside reverse transcriptase inhibitors
    US-9718819-B2August 01, 2017Merck Sharp & Dohme Corp.Non-nucleoside reverse transcriptase inhibitors